Shc Construct

Ligand

T (˚C)

Kd (µM)

ΔH (kJ/mol)

ΔCp (kJ/mol∙K)

−TΔS (kJ/mol)

ΔG (kJ/mol)

PTB Domain

bi-β3

25

5.14

−22.98

−0.88

−7.191

−30.17

12

4.32

−11.52

−17.75

−29.27

c-β3

25

0.35

−25.41

−0.09

−11.45

−36.86

12

1.05

−24.18

−8.446

−32.63

Full Length

bi-β3

25

2.84

−28.82

−0.96

−2.784

−31.60

12

5.21

−16.27

−12.55

−28.82

c-β3

25

1.33

−7.40

1.04

−26.13

−33.53

12

0.82

−21.03

−12.17

−33.20