Compound

Inhibition of E. Coli (PNP)

Inhibition of XAO

Substrate

M2 Guo

Conc. (μM)

IC₅₀

(μM)

Substrate

(Hx)

Conc. (μM)

IC₅₀

(μM)

2a

~

32

131

~500

~600

~

50

~700

3a

~

32

131

~700

~700

~

45

~900

3f

~

32

131

~500

~600

~

60

~500

3e

~

32

131

~400

~500

~

65

~500

4

~

32

131

~700

~800

~

48

~700

5

~

32

131

~600

~700

~

60

~600