Standard run | Composition parameters | Experimental observed | Predictions | |||||
PLGA (%w/v) | Cip-HCl (%w/v) | PVA (%w/v) | Size (nm) | DR (%w/w) | DL (%w/w) | Size (nm) | DR (%w/w) | |
1 | 1.0 | 0.5 | 0.1 | 443 | 5.85 | 1.125 | 443.00 | 5.85 |
2 | 1.0 | 1.0 | 0.3 | 235 | 3.70 | 1.490 | 237.33 | 4.89 |
3 | 1.0 | 1.5 | 0.2 | 302 | 1.70 | 0.990 | 299.67 | 0.51 |
4 | 1.5 | 0.5 | 0.3 | 372 | 15.70 | 1.455 | 369.67 | 14.51 |
5 | 1.5 | 1.0 | 0.2 | 384 | 4.28 | 1.425 | 384.00 | 4.28 |
6 | 1.5 | 1.5 | 0.1 | 436 | 2.96 | 1.155 | 438.33 | 4.15 |
7 | 2.0 | 0.5 | 0.2 | 347 | 8.86 | 1.055 | 349.33 | 10.05 |
8 | 2.0 | 1.0 | 0.1 | 358 | 5.28 | 1.055 | 355.67 | 4.09 |
9 | 2.0 | 1.5 | 0.3 | 353 | 3.21 | 1.120 | 353.00 | 3.21 |
Validation and optimization experiments | ||||||||
1 V | 1 | 0.2 | 0.1 | 530 | 7.83 | 1.618 | 558.84 | 10.01 |
2 V | 1 | 0.5 | 0.4 | 202 | 8.49 | 1.301 | 215.00 | 19.38 |