Drug | Dose | Days of administration | |
Induction (Protocol I) Phase A (SR/IR) |
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| |
Prednisone (PO) Vincristine (IV) Daunorubicin (PI, 1 hour) L-Asparaginase (PI, 1 hour) Methotrexate (IT) | 60 mg/m2/per day 1, 5 mg/m2/per dose 30 mg/m2/per dose 5000 IU/m2/per dose 12 mg per dose | 1 - 28a 8, 15, 22, 29 8, 15, 22b, 29b 12, 15, 18, 21, 24, 27, 30, 33 1, 12 | |
Induction (Protocol I) Phase B (SR/IR) |
|
| |
Cyclophosphamide (PI, 1 hour) Cytarabine (ARA-C)* (PI, 1 hour) 6-Mercaptopurine (PO) Methotrexate (IT) | 1000 mg/m2/per dose 75 mg/m2/per dose 60 mg/m2/per dose 12 mg per dose | 36, 64 (38 - 41), (45 - 48), (52 - 55), (59 - 62) 33 - 63 45, 49 | |
Consolidation (Protocol M) (pre B ALL, SR) |
|
| |
6-Mercaptopurine (PO) Methotrexate (PI, 24 hours) Methotrexate (IT) | 25 mg/m2/per day 2 g/m2/per dose 12 mg per dose | 1 - 56 8, 22, 36, 50 8, 22, 36, 50 | |
Consolidation (Protocol M) (pre B ALL IR and T ALL, SR/IR) |
|
| |
6-Mercaptopurine (PO) Methotrexate (IV, 24 hours) Methotrexate (IT) | 25 mg/m2/per day 5 g/m2/per dose 12 mg per dose | 1 - 56 8, 22, 36, 50 8, 22, 36, 50 | |
Reinduction (Protocol II) Phase 1 (SR/IR) |
|
| |
Dexamethasone (PO) | 10 mg/m2/per day | 1 - 21a | |
Vincristine (IV) | 1.5 mg/m2 | 8, 15, 22, 29 | |
Adriamycin (IV, 1 hour) | 30 mg/m2/per dose | 8, 15, 22, 29 | |
L-asparaginase (IV, 1 hour) | 5000 IU/m2 per dose | 8, 15, 22, 29 | |
Reinduction (Protocol II) Phase 2 (SR/IR) |
|
| |
Cyclophosphamide (PI, 1 hour) Cytarabine (PI, 1 hour) 6-Thioguanine (PO) Methotrexate (IT) | 1000 mg/m2/per dose 75 mg/m2/per dose 60 mg/m2/per day 12 mg per dose | 36 38 - 41, 45 - 48 36 - 49 38, 45 |